trRosetta

cd /home/pdiep/scratch/trrosetta/trDesign/02-GD

sbatch run.sh

MSA:

look for conservative sites in a family (sequence-based)

trRosetta MSA:

structural prediction based on a family (structure based)

Pipeline

input sequence -> trRosetta -> predicted features (theta, phi, dist, omega)

loss: compared with target structure (LCC)

loss -> back prop -> PSSM (position specific scoring matrix)

PSSM (input) -> trRosetta